Full-time researcher, Shenzhen Samii Medical Center

Postdoctor of Pharmacology, Peking University

Doctor of Pharmacology, Peking Union Medical College

Main Research Field
(1) Photodynamic and Sonodynamic Therapy

(2)Ultrasound Neuromodulation in the Treatment of Brain Diseases

Representative Research Achievements

1. Photosensitizers are administered orally or intravenously, and then activated by semiconductor laser or ultrasound to produce reactive oxygen species (mainly¹O₂), leading to a series of biological reactions. They can be used in the treatment of cancer, nevus flammeus, fundus macular disease, etc. We mainly screened and optimized photosensitizers, and evaluated their pharmacological activity and safety.

2. Optogenetic technology, one of the greatest innovations in the 20^thcentury, is an advanced technological means to study the pathogenesis of mental diseases, especially the changes in neural circuits. The essence of optogenetics is to achieve neuromodulation through light-gated proteins. In recent years, ultrasonic neuromodulation technology has attracted much attention. We aim to create a set of ultrasound-based genetic technologies to find appropriate voice-gated protein or ion channels to realize acoustic gene regulation and make it a new weapon for the treatment of neurological diseases.

Representative SCI Papers Published

(1) An Ya-Wen; Jin Hong-Tao; Yuan Bo; Wang Jian-Chun; Wang Cheng;Liu Han-Qing^*; Research progress of berberine mediated photodynamic therapy, Oncology Letters, 2021, 21 (5): 359. IF=2.967.

(2) An Ya-Wen; Yuan Bo; Wang Jian-Chun; Wang Cheng; Liu Ting-Ting; Song Shuo^*; Liu Han-Qing^*; Clinical characteristics and impacts of traditional Chinese medicine treatment on the convalescents of COVID-19, International Journal of Medical Sciences,2021; 18 (3): 646–651. IF=3.738.